Radiation dermatitis is a common side effect in the breast cancer patient receiving radiation therapy. This reaction causes increased pain and ultimately decreased quality of life. The purpose of this article is to introduce the reader to products that are currently being used or have been used in clinical studies for radiation therapy and wound care. The goal is to determine which products decrease pain and promote healing in breast cancer patients with radiation dermatitis. Ultimately, nurse practitioners will be able to use this as a guide in understanding and treating breast cancer patients who present with radiation dermatitis.