Now showing items 1-6 of 6
Role of the N-terminal region of troponin T in cardiac muscle contractile activation
Cardiac muscle contraction is the result of coordinated interactions between the contractile regulatory proteins of the thick and thin filaments, and a detailed understanding of how they interact is central to advancing ...
ROLE OF THE C-TERMINAL REGION OF CARDIAC TROPONIN I IN THIN FILAMENT REGULATION
Abnormal contraction and/or relaxation of cardiac muscle can cause heart diseases, heart failure, or even death. Contractile behavior of cardiac muscle is regulated by a series of Ca
FUNCTIONAL EFFECTS OF THE H1-HELIX AND THE FLEXIBLE-LINKER OF CARDIAC TROPONIN T IN HEALTH AND DISEASE
Mutations in cardiac contractile proteins are associated with heart diseases, but it is not understood how such alterations to proteins cause contractile dysfunction. Force generation and contraction of the heart is mediated ...
The role of cardiac troponin T-troponin I interactions in regulating cardiac function in health and disease
Alterations of cardiac contractile proteins are a known cause or consequence of heart disease; however, little is known about how particular alterations in cardiac contractile proteins affect contractile function. ...
EFFECTS OF MYOSIN HEAVY CHAIN ISOFORMS AND CARDIOMYOPATHY MUTATIONS ON SARCOMERE LENGTH-DEPENDENT ACTIVATION
Heritable mutations in cardiac muscle proteins lead to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. There is a lack of knowledge on how HCM/DCM-related mutations alter the molecular ...
EFFECTS OF CARDIOMYOPATHY-RELATED MUTATIONS IN THE N-TERMINUS OF CARDIAC TROPONIN T AND IMPLICATIONS FOR CARDIAC DYSFUNCTION
Hypertrophic cardiomyopathy (HCM)-related mutations in the N-terminus of cardiac troponin T (TnT) are associated with cardiac dysfunction and a high incidence of sudden cardiac death, however, the primary myofilament ...