Humans face extraordinary difficulties in reproduction, as over 10% of all pregnancies are aneuploid. In most cases, aneuploidy causes complications in development; indeed, it is the leading known cause of miscarriage and ...

Next generation sequencing technologies allow us to assemble genomes in days, with the primary advantage of producing large volumes of inexpensive data. The introduction of these technologies is changing our ability to ...

Flavobacterium psychrophilum is the etiologic agent of bacterial coldwater disease (CWD) and rainbow trout fry syndrome (RTFS) in salmonids. Presently there are no licensed vaccines for this disease, but earlier work showed ...

In humans, a striking 20-30% of all pregnancies are aneuploid and, of these, 95% result from missegregation during maternal meiosis. To date the only molecular mechanism associated with human aneuploidy is errors in ...

Chromosome segregation errors during meiosis pose a significant threat to the survival of a species, because aneuploidy that arises due to segregation errors can lead to the demise of any resulting embryos. Therefore, ...

Developmental exposures to estrogenic chemicals are postulated to cause spermatogenic impairment and associated male reproductive disorders in humans. Consistent with this, male rodents exposed prenatally and/or postnatally ...

The mouse and human genomes are saturated with retrotransposons or repetitive elements. While most repetitive elements cannot mobilize by themselves, a specific class of retrotransposon, Long Interspersed Element Type 1 ...

Genomic diversity between hatchery and wild salmonids is thought to underlie differential survival rates in the wild. Decreased survival may result from a hatchery fish's inability to properly respond to a predator. In ...

Compelling evidence from human populations worldwide suggest that sperm counts have declined by ~50% over the last 40 years. It is thought perinatal exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A ...