RSS 1.0Electronic Dissertations and Theses - Veterinary Medicine
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This collection contains theses and dissertations by students in the College of Veterinary Medicine at Washington State University.
Recent Submissions
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ENVIRONMENTAL EFFECTS ON SPERMATOGENESIS
(2018)Compelling evidence from human populations worldwide suggest that sperm counts have declined by ~50% over the last 40 years. It is thought perinatal exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A ... -
REGULATION, FUNCTION AND POTENTIAL APPLICATIONS OF MICROCIN PDI FOR MEDICINE AND FOOD SAFTEY
(2018)Microcin PDI (mccPDI) is a class IIa microcin that is encoded as a five-locus genetic unit that is borne by a conjugative plasmid. The microcin was first discovered in Escherichia coli strains 25 and 264 (cattle origin) ... -
Identifying intracellular roles of the Salmonella invasion-associated injectisome
(2018)Intracellular pathogens either reside within host-derived vacuoles or escape this compartment to inhabit the cytosol. Why some bacteria lyse their internalization vacuole and others cannot remains enigmatic in Gram-negative ... -
ENHANCING SPERM PRODUCTION IN THE BULL
(2018)Spermatogenesis is a complex process highly regulated mainly by somatic cells of testes, the Sertoli cells. The number of Sertoli cells for a male is fixed between birth and puberty, and does not increase after puberty ... -
BABESIA BIGEMINA TICK STAGE SPECIFIC GENES DURING PARASITE DEVELOPMENT WITHIN ADULT FEMALE RHIPICEPHALUS MICROPLUS
(2018)Babesia bigemina is an intra-erythrocytic parasite that infect cattle and transmitted by tick vectors transovarian transmission. This parasite causes bovine babesiosis (tick cattle fever) and has enormous veterinary, ... -
Analysis of the anti-migraine effects of THC using home cage wheel running
(2017)Migraine is a common neurological disorder characterized by severe headache and depression of normal activity. Despite its marked prevalence, migraine is poorly treated and no new anti-migraine agents have emerged in over ... -
EFFECTS OF CARDIOMYOPATHY-RELATED MUTATIONS IN THE N-TERMINUS OF CARDIAC TROPONIN T AND IMPLICATIONS FOR CARDIAC DYSFUNCTION
(2017)Hypertrophic cardiomyopathy (HCM)-related mutations in the N-terminus of cardiac troponin T (TnT) are associated with cardiac dysfunction and a high incidence of sudden cardiac death, however, the primary myofilament ... -
Characterization of Ovine herpesvirus 2 putative glycoprotein Ov8
(2017)Malignant catarrhal fever (MCF) is a lymphoproliferative usually fatal disease of ungulates caused by several gammaherpesviruses in the genus Macavirus including alcelaphine herpesvirus 1 (AlHV-1) and ovine herpesvirus 2 ... -
HYPERTONIC TREATMENTS ENHANCE THE EFFICACY OF ANTIBIOTICS AGAINST BACTERIAL BIOFILM COMMUNITIES
(2017)Biofilm is a structured community of bacterial cells enclosed in a self-produced matrix of extracellular polymeric substance (EPS). Biofilms have long been implicated in bacterial infections that are mostly untreatable. ... -
MYCOPLASMA BOVIS ASSOCIATED DISEASES: MODELING STRESS AND ITS EFFECT ON BOVINE IMMUNE FUNCTION
(2017)Mycoplasma bovis associated diseases are newly emerging causing significant economic losses in the cattle industry. Therefore, it is necessary to understand the pathogenesis of M. bovis to develop new preventive methods ... -
Disentangling the wicked problem of antibiotic resistance
(2017)Antimicrobial resistance (AMR) is currently an urgent public health concern worldwide. For low-income regions such as sub-Saharan Africa, absence of surveillance data and systematic investigations of risk factors prevents ... -
The role of excreted antibiotics in the establishment of persistent on-farm reservoirs of antibiotic-resistant bacteria
(2016)Bioavailable antibiotic residues from treated animals likely contribute to the persistence of antibiotic-resistant bacteria in agricultural systems. To determine the magnitude of this effect, we evaluated changes in the ... -
COMPARATIVE INVESTIGATION OF THE IMMUNE SYSTEMS OF TWO OVINE SPECIES (OVIS ARIES AND OVIS CANADENSIS)
(2016)Chapter 1 describes the economic and ecologic significance of respiratory disease in domestic sheep (DS; Ovis aries) and bighorn sheep (BHS; Ovis canadensis) and the need for interspecies comparative immune analyses. In ... -
SLEEP DISTURBANCES AFTER CHRONIC ALCOHOL CONSUMPTION: HOMEOSTATIC DYSREGULATION OR CIRCADIAN DESYNCHRONY?
(2016)Chronic alcohol use often leads to sleep disturbances such as insomnia and sleep fragmen¬ta¬¬tion, but the underlying mecha¬nisms are not fully understood. Sleep is regulated by two main processes: a homeo¬static process ... -
CHANNELING SATIATION AT THE ST-NTS SYNAPSE: THE ROLES OF TRP CHANNELS
(2016)Vagal afferent neurons relay meal-related signals from the gut to the hindbrain nucleus of the solitary tract (NTS) providing key controls of feeding and gastrointestinal reflexes. Centrally, vagal afferents form strong ... -
IMMUNIZATION STRATEGIES FOR THE CONTROL OF MANNHEIMIA HAEMOLYTICA PNEUMONIA IN BIGHORN SHEEP
(2016)Mannheimia haemolytica is an important pathogen of pneumonia in bighorn sheep (BHS, Ovis canadensis). Leukotoxin is the critical virulence factor of this bacterium. In an earlier study, an experimental vaccine containing ... -
FUNCTIONAL CHARACTERIZATION OF THE BACTERIAL MICROBIOME OF THE DERMACENTOR ANDERSONI TICK EXHIBITS INTERACTIONS WITH PATHOGEN ACQUISITION
(2016)Ticks are obligate hematophagous arthropods that feed on vertebrates and are of importance due to their ability to inflict harm to humans and animals. In particular, ticks transmit pathogens throughout all continents and ... -
Protective effects of an experimental sporozoite-based immunization strategy against Theileria equi
(2016)Theileria equi is a tick-transmitted apicomplexan hemoparasite parasite of equids with a worldwide distribution and a cause of equine piroplasmosis, a World Organization of Animal Health (OIE) reportable disease. Although ... -
IDENTIFICATION AND ANALYSIS OF REGULATORY AND SEXUAL STAGE GENES IN THE GENOMES OF BABESIA AND THEILERIA PARASITES
(2016)The tick borne apicomplexan parasites Babesia and Theileria are responsible for costly and devastating diseases globally. Improved control is needed but the biology of these parasites remains poorly understood. Significant ... -
ELUCIDATING MECHANISMS FOR PERSISTENT INFECTION BY THE RELAPSING FEVER SPIROCHETE BORRELIA HERMSII
(2016)Relapsing fever is a tick-borne bacterial disease caused by a number of species in the genus Borrelia. Persistence is a key component of the lifecycle of relapsing fever Borrelia as it improves the chance for tick acquisition ...