Browsing Electronic Dissertations and Theses - Veterinary Medicine by Title
Now showing items 15-34 of 79
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DECIPHERING MECHANISMS OF VLSE-MEDIATED IMMUNE AVOIDANCE BY BORRELIA BURGDORFERI
(2014)The current work has focused on antigenic variation of the VlsE surface lipoprotein, a key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, -
Diagnosis of Mycoplasma Mastitis: Validation and Development
(2010)Microbiological culture of milk samples has been used as a standard diagnosis for mycoplasma mastitis. It is suggested to perform with fresh samples for optimum diagnosis. Submission of fresh samples is often difficult ... -
Disentangling the wicked problem of antibiotic resistance
(2017)Antimicrobial resistance (AMR) is currently an urgent public health concern worldwide. For low-income regions such as sub-Saharan Africa, absence of surveillance data and systematic investigations of risk factors prevents ... -
EFFECTS OF CARDIOMYOPATHY-RELATED MUTATIONS IN THE N-TERMINUS OF CARDIAC TROPONIN T AND IMPLICATIONS FOR CARDIAC DYSFUNCTION
(2017)Hypertrophic cardiomyopathy (HCM)-related mutations in the N-terminus of cardiac troponin T (TnT) are associated with cardiac dysfunction and a high incidence of sudden cardiac death, however, the primary myofilament ... -
EFFECTS OF MYOSIN HEAVY CHAIN ISOFORMS AND CARDIOMYOPATHY MUTATIONS ON SARCOMERE LENGTH-DEPENDENT ACTIVATION
(2019)Heritable mutations in cardiac muscle proteins lead to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. There is a lack of knowledge on how HCM/DCM-related mutations alter the molecular ... -
ELECTRICAL AND CHEMICAL MANIPULATION OF CORTICAL NETWORK STATES IN VITRO
(2014)Despite its profound impact on humanity, very little is known about the cellular and biochemical regulation sleep. A local use-dependent theory of sleep posits that sleep-wake cycling emerges through the consolidation and ... -
ELUCIDATING MECHANISMS FOR PERSISTENT INFECTION BY THE RELAPSING FEVER SPIROCHETE BORRELIA HERMSII
(2016)Relapsing fever is a tick-borne bacterial disease caused by a number of species in the genus Borrelia. Persistence is a key component of the lifecycle of relapsing fever Borrelia as it improves the chance for tick acquisition ... -
ENDOGENOUS AND EXOGENOUS INFLUENCES ON MAMMALIAN MALE MEIOTIC PROPHASE
(2014)Developmental exposures to estrogenic chemicals are postulated to cause spermatogenic impairment and associated male reproductive disorders in humans. Consistent with this, male rodents exposed prenatally and/or postnatally ... -
ENHANCING SPERM PRODUCTION IN THE BULL
(2018)Spermatogenesis is a complex process highly regulated mainly by somatic cells of testes, the Sertoli cells. The number of Sertoli cells for a male is fixed between birth and puberty, and does not increase after puberty ... -
ENVIRONMENTAL EFFECTS ON SPERMATOGENESIS
(2018)Compelling evidence from human populations worldwide suggest that sperm counts have declined by ~50% over the last 40 years. It is thought perinatal exposure to endocrine disrupting chemicals (EDCs), such as bisphenol A ... -
ESTABLISHMENT OF SPERMATOGENESIS FOLLOWING TESTICULAR TISSUE ECTOPIC XENOGRAFTING IN ALPACA
(2013)Sperm production depends on development, puberty and germ cell differentiation. Puberty age of alpaca varies and little is known of factors regulating this process. The species is also known for a high incidence of congenital ... -
Extracellular cues shape GABAergic transmission in the developing hippocampus: the case of leptin
(2014)The present dissertation tackles the larger question of how external cues, including sensory stimulation, neuronal activity, neurotrophins and soluble factors from the periphery (hormones) impact the development of the ... -
Factors involved in the proliferation of blaCMY-2 plasmid-bearing Escherichia coli in cattle
(2011)Third-generation cephalosporins are a crucial component of the antibiotic arsenal for human and veterinary medicine. Resistance to third-generation cephalosporins is often conveyed by blaCMY-2 plasmids. The prevalence of ... -
Fatty acid epoxides produced by cytochrome P450s mediate the deleterious effects of dietary DGLA in the C. elegans germ line
(2015)Polyunsaturated fatty acids (PUFAs) are precursors to bioactive molecules which play essential roles in development, immune response, and reproduction. This process is moderated by three pathways which act on PUFAs to form ... -
FUNCTIONAL CHARACTERIZATION OF THE BACTERIAL MICROBIOME OF THE DERMACENTOR ANDERSONI TICK EXHIBITS INTERACTIONS WITH PATHOGEN ACQUISITION
(2016)Ticks are obligate hematophagous arthropods that feed on vertebrates and are of importance due to their ability to inflict harm to humans and animals. In particular, ticks transmit pathogens throughout all continents and ... -
FUNCTIONAL EFFECTS OF THE H1-HELIX AND THE FLEXIBLE-LINKER OF CARDIAC TROPONIN T IN HEALTH AND DISEASE
(2015)Mutations in cardiac contractile proteins are associated with heart diseases, but it is not understood how such alterations to proteins cause contractile dysfunction. Force generation and contraction of the heart is mediated ... -
Genomic and Behavioral Diversity in Rainbow Trout
(2013)Genomic diversity between hatchery and wild salmonids is thought to underlie differential survival rates in the wild. Decreased survival may result from a hatchery fish's inability to properly respond to a predator. In ... -
Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition
(2014)Pneumonia is the most important disease of bighorn sheep (BHS). Pathogens detected in pneumonic BHS lungs include Mannheimia haemolytica, Bibersteinia trehalosi, Pasteurella multocida and Mycoplasma ovipneumoniae. Although ... -
HYPERTONIC TREATMENTS ENHANCE THE EFFICACY OF ANTIBIOTICS AGAINST BACTERIAL BIOFILM COMMUNITIES
(2017)Biofilm is a structured community of bacterial cells enclosed in a self-produced matrix of extracellular polymeric substance (EPS). Biofilms have long been implicated in bacterial infections that are mostly untreatable. ... -
IDENTIFICATION AND ANALYSIS OF REGULATORY AND SEXUAL STAGE GENES IN THE GENOMES OF BABESIA AND THEILERIA PARASITES
(2016)The tick borne apicomplexan parasites Babesia and Theileria are responsible for costly and devastating diseases globally. Improved control is needed but the biology of these parasites remains poorly understood. Significant ...