Now showing items 1-4 of 4
Characterization of Cobalamin-Dependent Radical S-Adenosyl-L-Methionine Methyltransferases Involved in Antibiotic Biosynthesis
Due to increasing antibiotic resistance among dangerous pathogens, there is a critical need for new antibiotics. Enzymes represent a powerful tool for antibiotic production and discovery, however more enzymatic mechanisms ...
ROLE OF THE C-TERMINAL REGION OF CARDIAC TROPONIN I IN THIN FILAMENT REGULATION
Abnormal contraction and/or relaxation of cardiac muscle can cause heart diseases, heart failure, or even death. Contractile behavior of cardiac muscle is regulated by a series of Ca
UNCOVERING A REGION IN THE NIPAH VIRUS ATTACHMENT PROTEIN IMPORTANT FOR TRIGGERING MEMBRANE FUSION
Membrane fusion is essential for entry of the biomedically-important Nipah virus (NiV) into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by NiV infections. For NiV, ...
EFFECTS OF MYOSIN HEAVY CHAIN ISOFORMS AND CARDIOMYOPATHY MUTATIONS ON SARCOMERE LENGTH-DEPENDENT ACTIVATION
Heritable mutations in cardiac muscle proteins lead to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. There is a lack of knowledge on how HCM/DCM-related mutations alter the molecular ...