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The role of intracellular signaling pathways on mu-opioid receptor agonist induced antinociception and tolerance development
Mu-opioid receptor (MOPr) agonists, such as morphine and fentanyl, are the most commonly prescribed drugs to alleviate severe and chronic pain. Although all agonists produce antinociception, they vary in terms of activation ...
The Effects of Chronic Psychostimulant Exposure on Morphine-Induced Antinociception and Tolerance
Pre-weanling methylphenidate (MPH) exposure enhances systemic morphine-induced antinociception and tolerance in adult rats. This finding raises questions about the brain area(s) involved, the importance of developmental ...
Sex Differences in Morphine-Induced Antinociception and Reward Using a Chronic Inflammatory Pain Model in Rats
There is a species difference between rodents and humans in the sexual dimorphism of morphine analgesia. Women self-administer less morphine than men suggesting morphine produces greater analgesia in that sex. In contrast, ...