RSS 1.0Electronic Dissertations and Theses - Pharmacy
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This collection contains theses and dissertations by students in the College of Pharmacy at Washington State University.
Recent Submissions
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Characterization and pharmacogenetics of hepatic phase I exemestane metabolism
(2017)Exemestane (EXE) is an endocrine therapy used to combat postmenopausal breast cancer. Several studies have reported substantial differences in clinical outcomes between EXE-treated patients, as well as inexplicable ... -
Development of hysteresis analysis as a model-independent approach to assess temporal dissociation in pharmacokinetics and pharmacodynamics
(2016)Pharmacodynamic hysteresis is a loop, typically anti-clockwise, in the effect-concentration profile, resulting from temporal dissociation between elaboration of effect and changes in drug concentration. Hysteresis behavior ... -
Diabetic cardiomyopathy: phenotypes, mechanisms, and therapeutic targets
(2015)Diabetic cardiomyopathy (DCM) is a syndrome of cardiac dysfunction, fibrosis, and hypertrophy that is often associated with type 2 diabetes mellitus (T2DM) independent of classical risk factors for cardiovascular disease. ... -
Characterization of the effects of free fatty acid receptor 4 (FFA4) agonists on human cancer cells
(2015)Dietary omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have many beneficial effects on human health. These include promising inhibitory effects on cancer cell growth and invasion. ... -
An Integrative Systems Approach to Predict Herb-Drug Interactions Quantitatively
(2015)Consumers often supplement their drug regimens with alternative therapies, including herbal products. Despite this widespread practice, reliable information to determine the risk or safety of herb-drug interactions is ... -
A Proposed Mechanism for Transcriptional Regulation of Cardiac Hypertrophy
(2014)Conventional medical therapies for treatment of hypertension center around symptom management, and this is due, in part, to limited understanding of the mechanisms responsible for hypertrophy, remodeling, and progression ... -
NOVEL THERAPEUTICS AND PATHOMECHANISMS IN HUMAN MENDELIAN DISORDERS: PHENYLKETONURIA, MAPLE SYRUP URINE DISEASE, AND SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY
(2014)The body of this dissertation is focused on understanding the pathomechanisms and paving the way for new treatment paradigms in human metabolic disease, particularly phenylketonuria (PKU), maple syrup urine disease (MSUD), ... -
INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY
(2013)Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins. PARG participates ... -
DEVELOPMENT OF THERAPEUTICS TARGETING THE HEPATOCYTE GROWTH FACTOR(HGF)/MET SYSTEM
(2011)In this dissertation I will describe the development of prototype small molecule therapeutics directed at the HGF/Met system. In addition I will introduce a new approach for quantitatively localizing Met at the sub-cellular ... -
Pharmacokinetics, Pharmacodynamics, and Formulation Development of Hydrophobic Xenobiotics
(2011)Natural products are a reservoir of potential therapeutic agents. One such class of compounds are the polyphenols, small molecular weight compounds found in a range of plant sources that exhibit potent anti-cancer, ... -
Analytical Method Development, Pharmacokinetics, and Pharmacodynamics of Selected Polyphenols
(2010)Novel analytical methods were developed and validated according to the International Conference on Harmonization guidelines using high-performance liquid chromatography (HPLC) with ultraviolet (UV) and/or electrospray ...