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dc.contributor.advisorMcLean, Derek J.
dc.creatorCaires, Kyle Cody
dc.date.accessioned2011-08-19T21:58:17Z
dc.date.available2011-08-19T21:58:17Z
dc.date.issued2011
dc.identifier.urihttp://hdl.handle.net/2376/2856
dc.descriptionThesis (Ph.D.), Animal Sciences, Washington State Universityen_US
dc.description.abstractSpermatogonial stem cells (SSCs) are the only adult stem cell population capable of transmitting genetics to offspring and accomplish this feat through the production of spermatozoa. Indeed, spermatogenesis yields a virtually unlimited supply of gametes throughout the lifespan of the male as a result of coordinated SSC differentiation and self-renewal. In essence, SSCs are the keepers of the male germ-line and this population originates from primitive germ cell lineages during neonatal life in a species-specific manner. SSCs, like other adult stem cells, are thought to reside in a niche microenvironment that must be established and maintained in the seminiferous tubules of the neonatal and adult testis. Extrinsic signals produced by somatic cells within the niche act to direct the cell fate of SSCs by either supporting self-renewal or initiating differentiation leading to meiotic entry and production of spermatozoa. Despite the importance of these processes, little is known about the biochemical and cellular mechanisms that govern SSC homeostasis and identity due to the lack of SSCs specific biomarkers and complex cell biology of the testis. These challenges underscore the importance of functional stem cell transplantation for investigating the role of endocrine and locally produced factors that regulate the biological activity of SSCs. Moreover, donor-derived spermatogenesis after transplantation is the only reliable and accurate means to identify a bonafide SSC in a cell population and assay SSC self-renewal in responseen_US
dc.language.isoEnglish
dc.rightsIn copyright
dc.rightsLimited public access
dc.rightsrestrictedAccess
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.rights.urihttp://www.ndltd.org/standards/metadata
dc.rights.urihttp://purl.org/eprint/accessRights/RestrictedAccess
dc.subjectAnimal Sciencesen_US
dc.subjectPhysiologyen_US
dc.subjectDevelopmental Biologyen_US
dc.subjectAdult Stem Cellsen_US
dc.subjectGamete Biologyen_US
dc.subjectGrowth Factorsen_US
dc.subjectSpermatogenesisen_US
dc.subjectSpermatogonial Stem Cellsen_US
dc.subjectTestisen_US
dc.titleINVESTIGATION OF FACTORS REGULATING SPERMATOGONIAL STEM CELL HOMEOSTASIS IN THE MAMMALIAN TESTIS
dc.typeElectronic Thesis or Dissertation


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