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Application of Hadamard Transform Ion Mobility Mass Spectrometry to Global Metabolomics
Conventional Ion mobility mass spectrometry (IMMS) provides rapid separation and detection of complex mixtures. It is merging as a powerful analytical platform for the field of metabolomics but is limited in throughput. ...
EFFECT OF IRON-NITROGEN COORDINATION (TYPE II BINDING) ON DRUG METABOLISM BY CYTOCHROME P450: STUDIES TO UNDERSTAND THE KINETICS, METABOLIC STABILITY AND REGIOSELECTIVITY
Cytochrome P450 (CYP) enzymes metabolize more than 80% of clinically used drugs. Given a large role of CYP enzymes in drug metabolism, one of the goals in pharmaceutical industry is to understand metabolic rate and ...
Development of Phosphoramidate Inhibitors for Cell Surface Proteases in Metastatic Cancers
The development of highly tuned diagnostic agents are critical for the early detection of cancer and are commonly designed to bind cell surface receptors. A small library of first-generation phosphoramidate inhibitors ...
ELECTROCHEMICAL INVESTIGATIONS OF DOPAMINE USING ROTATING DISK ELECTRODE VOLTAMMETRY: STUDY OF RELEASE AND REUPTAKE KINETICS AND INHIBITION OF THE NEURONAL DOPAMINE TRANSPORTER
The dopamine transporter (DAT) is the neuronal transporter for the neurotransmitter dopamine (DA). The use of rotating disk electrode voltammetry (RDEV) is a technique used to study transport of DA by DAT. This can be done ...
TOWARDS UNDERSTANDING DIRIGENT PROTEIN FUNCTION
Plants produce a dazzling collection of chemical compounds with great structural and functional diversity that are known as specialized metabolites which have important roles in plant defense responses. Most significantly, ...