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Application of the asymmetric [C+NC+CC] coupling reaction to synthesis
The asymmetric [C+NC+CC] coupling reaction provides stereoselective access to highly functionalized pyrrolidine rings. The hallmark of this azomethine ylide cycloaddition cascade is the ability to successfully employ ...
Inhibition and Absolute Quantitation of Human Aldehyde Oxidase
In recent years, aldehyde oxidase (AO) has continued to grow as an important enzyme in drug metabolism. Herein, we have focused primarily on the inhibition kinetics of AO and also developing tools to better understand AO ...
NEW METHODS FOR THE CONVERGENT GLYCOLIGATION OF PEPTIDES
The attachment of oligosaccharides (glycans) to proteins is an important co- and post-translational modification which greatly expands the functional and structural diversity of a proteome. As glycosylation is integral to ...
BIOLOGICAL PEPTIDE INTERACTIONS WITH CELLULAR MEMBRANES
Eukaryotic cell membrane dynamics change in curvature during physiological and pathological processes. These processes cause dynamic membrane changes leading to seven important cellular biological functions, which include ...