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Optimizing the Enzyme/Prodrug Axis of Suicide Gene Therapy Using Protein Engineering Strategies
The unifying goal of cancer therapy is to selectively eradicate cancer cells while sparing normal tissue from damage. As many current anticancer therapies lack specificity and cause unwanted side effects there is an unmet ...
CALCIUM/CALMODULIN-BINDING PROTEINS AND THEIR ROLE IN REPRODUCTIVE DEVELOPMENT AND STRESS RESPONSES IN PLANTS
It has been well documented that calcium/calmodulin signaling plays important roles in plant growth, development and responses to environmental stimuli. In recent years, a variety of calcium/calmodulin-binding proteins ...
Arabidopsis Arogenate Dehydratases: Influence on Aromatic Amino Acid and Downstream Phenylpropanoid Biosynthesis
Arogenate dehydratases (ADTs) perform the final step of phenylalanine (Phe) biosynthesis in plants. As one of twenty protein-coding amino acids, Phe is essential in all living organisms, and in plants it is also a precursor ...
STABILIZING INTERACTIONS IN THE H2A-H2B MONOMERIC AND DIMERIC KINETIC INTERMEDIATES
The long-standing goal of protein folding studies is to understand how the amino acid sequence encodes the folding of a peptide from an extended conformation to the biologically active, three-dimensional structure. ...
SPECIFIC RESIDUES WITHIN HISTONE H2B REGULATE YEAST GENE EXPRESSION AND SILENCING, HISTONE H3 METHYLATION AND THE RESPONSE TO DNA DAMAGE
The histone proteins H3 and H4 have been extensively studied and are known to play well characterized roles in the regulation of yeast gene expression, silencing and the response to DNA damage. In contrast, relatively ...