Migraine headache occurs in 6% ofmales and 18% of females. The process of migraine is believed to be one of vascular, neurochemical, neuronal and hormonal changes. Severe migraine pain can be disabling, and mild to moderate pain can interfere with one's normal daily activities. Research has demonstrated a connection with depression and altered quality of life in migraneurs. Diagnosis of migraine is based on history, patient presentation, and exclusion of other pathology. Treatment options include preventive and abortive therapies. The goal of management is to reduce frequency and severity of episodes, and limit the impact of this chronic pain condition.