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dc.creatorHiscox, William C.
dc.creatorHelms, Gregory L.
dc.creatorRisinger, April L.
dc.creatorJackson, Evelyn M.
dc.creatorMooberry, Susan L.
dc.date.accessioned2012-06-26T18:32:25Z
dc.date.available2012-06-26T18:32:25Z
dc.date.issued3/27/2010
dc.identifier.urihttp://hdl.handle.net/2376/3859
dc.description.abstractTumors resistant to the potent anti-cancer drugs Paclitaxel and Doxorubicin are becoming increasingly problematic in the successful treatment of certain patients. A new class of microtubule stabilizing compounds isolated from plants of the genus Tacca have been found to have excellent anti-cancer activity in vivo against cell lines resistant to drugs of the taxane class. We report the structures of the most active compounds as Taccalonolide A, E, B and N as determined by NMR and comparison with published results as well as the structure of additional active components of differing structural classes.en_US
dc.description.sponsorshipWashington State Universityen_US
dc.languageEnglish
dc.rightsIn copyright
dc.rightsopenAccess
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.rights.urihttp://purl.org/eprint/accessRights/OpenAccess
dc.titleStructure determination and verification by NMR of potent microtubule stabilizing compounds isolated from the medicinal plant tacca chantrieri. Possible use in tumors resistant to paclitaxel and doxorubicin.
dc.typePresentation
dc.description.citationHiscox, William C. et al. Structure determination and verification by NMR of potent microtubule stabilizing compounds isolated from the medicinal plant tacca chantrieri. Possible use in tumors resistant to paclitaxel and doxorubicin. Poster presented at the Washington State University Academic Showcase, Pullman, WA.


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  • WSU Academic Showcase 2009
    This collection contains research and scholarly materials featured at the 2009 Academic Showcase at Washington State University.

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