A Comparison Between the Effects of 0.025% and 0.075% Capsaicin on Painful Diabetic Neuropathy
Gonzalez-Aller Solis, Mercedes
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The purpose of this study was to determine the difference between two different strengths of topical capsaicin cream on relieving the pain associated with diabetic neuropathy. This quasi-experimental single blind and randomized drug study evaluated 15 diabetics with painful peripheral neuropathy during treatment with 0.025% or 0.075% capsaicin. Neuropathy pain was assessed at baseline and at weeks 1, 3, 5, 7 and 8 by a vertical 1OOmm visual analog scale in which participants rated their most intense pain. Repeated measures analysis of variance showed no significant difference between the two available over-the-counter strengths of capsaicin (p=0.496) in relieving the pain associated with diabetic neuropathy. However, analysis of variance showed significant pain relief over time for both groups (p=O.OOO). Compliance with the study's treatment was evaluated by t-tests (t=0.520, df=1, p=0.612), and Pearson chi-square (x2=3.951, df=5, p=0.557) methods, which showed no significant difference between the two groups. The study concluded that capsaicin's 0.025% regular strength cream is as effective as the 0.075% extra-strength in relieving diabetic neuropathy pain.