Alzheimer's Disease: Advances in Theory and Treatment
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New strategies for disease-modifying treatment of Alzheimer's Disease are being developed as a result of advances in the understanding of the pathogenesis and underlying neurodegenerative processes. Identification of the heterogenous genetics of Alzheimer's Disease has demonstrated autosomal dominant and susceptibility genes which operate in different forms of the disease. Disease-modifying treatments involve neurotrophic factors, protein-processing modulators, antioxidants, anti-inflammatories, and estrogen. Nerve growth factor improves the survival of neurons. The control of oxidative stress and destructive inflammation may decrease the rate of neurodegeneration. Modulation of protein processing has the goal of decreasing the formation of neuritic plaques and neurofibrillary tangles. Basic research and clinical trials of candidate drugs may soon lead to more effective biologically-based treatments for Alzheimer's Disease.