Clearing the Air: Identifying Risk Factors of L-Methylfolate Deficiency for L-Methylfolate/Deplin® Intervention
Osgood, Candace R.
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This article summarizes the research findings surrounding the identified risk factors that disrupt the methylation process related to the synthesis of L-methylfolate. These risk factors could be included in the practitioners' comprehensive assessment as a tool to enable more accurate identification of patients who might benefit from utilizing L-methylfolate (Deplin®) as a psychiatric intervention. The risk factors that disrupt the methylation process include polymorphisms, certain medications, lifestyle choices, B12 deficiency and other indicators of possible methylation disruption including specific psychiatric disorders and medical diagnoses. With research demonstrating the safety and benefits of L-MTHF as a mono or adjunctive therapy this article proposes that it is a useful tool for practitioners' to increase positive patient outcomes.