Now showing items 91-100 of 177
FUNCTIONAL EFFECTS OF THE H1-HELIX AND THE FLEXIBLE-LINKER OF CARDIAC TROPONIN T IN HEALTH AND DISEASE
Mutations in cardiac contractile proteins are associated with heart diseases, but it is not understood how such alterations to proteins cause contractile dysfunction. Force generation and contraction of the heart is mediated ...
IN VITRO DRUG SUSCEPTIBILITY OF THEILERIA EQUI AND THE ROLE OF ABC TRANSPORTERS IN RESISTANCE TO IMIDOCARB DIPROPIONATE
The primary work presented involves evaluation of the apicomplexan hemoparasite Theileria equi for imidocarb dipropionate resistance, assessment of possible alternative treatment options, and investigation of the potential ...
The Role of the Nipah Virus G Head and Stalk Regions in Modulating Viral Fusion
Nipah virus (NiV) is an emerging zoonotic virus within the paramyxovirus family that causes severe neurological and respiratory disease in its victims and has mortality rates in humans of up to one hundred percent. Membrane ...
TRANSCRIPTOME ANALYSIS OF VIBRIO PARAHAEMOLYTICUS IN TYPE III SECRETION SYSTEM 1 INDUCING CONDITIONS
Vibrio parahaemolyticus is a bacterial pathogen capable of causing gastroenteritis, wound infections and septicemia. Its virulence factors include two type III secretion systems (T3SS1 and T3SS2) that cause host-cell ...
CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS
Salmonella enterica serovar Enteritidis (S. Enteritidis) is one of the most common serovars associated with poultry and poultry product contamination in the USA. We previously identified fifteen mutant strains of S. ...
SALMONELLA AND ANTIMICROBIAL RESISTANCE IN HUMANS, LIVESTOCK AND WILD BIRDS
Salmonella are Gram negative bacteria that are classified into over 2600 serovars. The serovars that cause typhoid fever are restricted to humans, whereas non-typhoidal Salmonella serovars (NTS) infect multiple hosts ...
DECIPHERING MECHANISMS OF VLSE-MEDIATED IMMUNE AVOIDANCE BY BORRELIA BURGDORFERI
The current work has focused on antigenic variation of the VlsE surface lipoprotein, a key mechanism for immune evasion and persistent infection by the Lyme disease spirochete,
RECTAL MICROBIOTA DYNAMICS IN PRE-WEANED DAIRY CALVES DEPENDING ON COLOSTRUM INTAKE, PRESENCE OF DIARRHEA AND ANTIBIOTIC TREATMENT
The mammalian intestine microbial community carries out many functions contributing to host's defense from infectious diseases, nutrition, growth, immunodevelopment and immunomodulation. Several factors such as diet, age, ...
UNCOVERING A REGION IN THE NIPAH VIRUS ATTACHMENT PROTEIN IMPORTANT FOR TRIGGERING MEMBRANE FUSION
Membrane fusion is essential for entry of the biomedically-important Nipah virus (NiV) into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by NiV infections. For NiV, ...
IDENTIFICATION OF GENES THAT REGULATE TYPE-III SECRETION SYSTEM I OF VIBRIO PARAHAEMOLYTICUS IN RESPONSE TO HOST-CELL CONTACT
Vibrio parahaemolyticus pandemic serotype O3:K6 causes acute gastroenteritis, wound infections and septicemia in humans. This organism encodes two type - III secretion systems (T3SS1 and T3SS2) of which host - cell ...