Now showing items 11-20 of 26
THE ROLE OF LIPID ANTIGENS IN THE PROTECTION AGAINST RHODOCOCCAL PNEUMONIA
Rhodococcus equi is an actinomycete bacterium that is closely to Mycobacterium tuberculosis. It is also an important cause of pneumonia in young horses worldwide. Like M. tuberculosis, R. equi persists within macrophages ...
TRANSCRIPTOME ANALYSIS OF VIBRIO PARAHAEMOLYTICUS IN TYPE III SECRETION SYSTEM 1 INDUCING CONDITIONS
Vibrio parahaemolyticus is a bacterial pathogen capable of causing gastroenteritis, wound infections and septicemia. Its virulence factors include two type III secretion systems (T3SS1 and T3SS2) that cause host-cell ...
SALMONELLA AND ANTIMICROBIAL RESISTANCE IN HUMANS, LIVESTOCK AND WILD BIRDS
Salmonella are Gram negative bacteria that are classified into over 2600 serovars. The serovars that cause typhoid fever are restricted to humans, whereas non-typhoidal Salmonella serovars (NTS) infect multiple hosts ...
DECIPHERING MECHANISMS OF VLSE-MEDIATED IMMUNE AVOIDANCE BY BORRELIA BURGDORFERI
The current work has focused on antigenic variation of the VlsE surface lipoprotein, a key mechanism for immune evasion and persistent infection by the Lyme disease spirochete,
UNCOVERING A REGION IN THE NIPAH VIRUS ATTACHMENT PROTEIN IMPORTANT FOR TRIGGERING MEMBRANE FUSION
Membrane fusion is essential for entry of the biomedically-important Nipah virus (NiV) into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by NiV infections. For NiV, ...
Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition
Pneumonia is the most important disease of bighorn sheep (BHS). Pathogens detected in pneumonic BHS lungs include Mannheimia haemolytica, Bibersteinia trehalosi, Pasteurella multocida and Mycoplasma ovipneumoniae. Although ...
Sex-specific differences in human meiotic recombination: A cytogenetic analysis of early meiotic events
In humans, a striking 20-30% of all pregnancies are aneuploid and, of these, 95% result from missegregation during maternal meiosis. To date the only molecular mechanism associated with human aneuploidy is errors in ...
ENDOGENOUS AND EXOGENOUS INFLUENCES ON MAMMALIAN MALE MEIOTIC PROPHASE
Developmental exposures to estrogenic chemicals are postulated to cause spermatogenic impairment and associated male reproductive disorders in humans. Consistent with this, male rodents exposed prenatally and/or postnatally ...
Extracellular cues shape GABAergic transmission in the developing hippocampus: the case of leptin
The present dissertation tackles the larger question of how external cues, including sensory stimulation, neuronal activity, neurotrophins and soluble factors from the periphery (hormones) impact the development of the ...
Molecular Mechanisms for Phosphoinositide Regulation of Cone Photoreceptor CNG Channel Gating
Photoreceptor cyclic nucleotide-gated (CNG) channels are critical for converting light inputs into electrical signals that are ultimately processed as visual information. However, it is not well understood how exactly ...