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COMPARATIVE INVESTIGATION OF THE IMMUNE SYSTEMS OF TWO OVINE SPECIES (OVIS ARIES AND OVIS CANADENSIS)
Chapter 1 describes the economic and ecologic significance of respiratory disease in domestic sheep (DS; Ovis aries) and bighorn sheep (BHS; Ovis canadensis) and the need for interspecies comparative immune analyses. In ...
IMMUNIZATION STRATEGIES FOR THE CONTROL OF MANNHEIMIA HAEMOLYTICA PNEUMONIA IN BIGHORN SHEEP
Mannheimia haemolytica is an important pathogen of pneumonia in bighorn sheep (BHS, Ovis canadensis). Leukotoxin is the critical virulence factor of this bacterium. In an earlier study, an experimental vaccine containing ...
Protective effects of an experimental sporozoite-based immunization strategy against Theileria equi
Theileria equi is a tick-transmitted apicomplexan hemoparasite parasite of equids with a worldwide distribution and a cause of equine piroplasmosis, a World Organization of Animal Health (OIE) reportable disease. Although ...
ELUCIDATING MECHANISMS FOR PERSISTENT INFECTION BY THE RELAPSING FEVER SPIROCHETE BORRELIA HERMSII
Relapsing fever is a tick-borne bacterial disease caused by a number of species in the genus Borrelia. Persistence is a key component of the lifecycle of relapsing fever Borrelia as it improves the chance for tick acquisition ...
THEILERIA PARVA: IMMUNOPATHOLOGY, CORRELATES OF PROTECTION, AND VACCINE DEVELOPMENT
East Coast Fever (ECF), caused by the apicomplexan parasite, Theileria parva, kills over a million cattle each year in sub-Saharan Africa. Cattle that develop ECF succumb to respiratory failure-induced pulmonary edema; ...
STRUCTURAL CHARACTERIZATION OF THE ANAPLASMA MARGINALE ANTIGENICALLY VARIANT MSP2 PROTEIN
Antigenic variation allows pathogens to escape host immune responses and establish persistent infection. Anaplasma marginale uses gene conversion from a genomic allelic repertoire to generate msp2 expression site variants. ...