Now showing items 1-10 of 11
Optimizing the Enzyme/Prodrug Axis of Suicide Gene Therapy Using Protein Engineering Strategies
The unifying goal of cancer therapy is to selectively eradicate cancer cells while sparing normal tissue from damage. As many current anticancer therapies lack specificity and cause unwanted side effects there is an unmet ...
STABILIZING INTERACTIONS IN THE H2A-H2B MONOMERIC AND DIMERIC KINETIC INTERMEDIATES
The long-standing goal of protein folding studies is to understand how the amino acid sequence encodes the folding of a peptide from an extended conformation to the biologically active, three-dimensional structure. ...
CHARACTERIZATION OF MITOCHONDRIAL AND CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASES
As a folate-dependent enzyme, serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of L-serine and (6S)-H4PteGlun (tetrahydrofolate, THF) to glycine and (6S)-5,10-CH2-H4PteGlun. The glycine-forming ...
Understanding the Physiological Significance of Ureide Transport Processes in Soybean (
The ureides allantoin and allantoic acid are the major long-distance forms of nitrogen (N) in nodulated tropical legumes like French bean (
Fundamental Mechanism and Impact of Post Translational Modifications on Calsequestrin: Implications for Function
Calsequestrin, the major resident protein found within the sarcoplasmic reticulum (SR), is a critical component required for proper muscle function. Exicitation-contraction coupling in muscle is regulated through fine ...
Genetic Pathways Involved in Omega-6 Fatty Acid-Induced Sterility in C. elegans
Polyunsaturated fatty acids serve both structural and functional roles as membrane components as well as precursors for a number of different factors involved in inflammation and signaling. Humans are unable to synthesize ...
Arabidopsis Arogenate Dehydratases: Influence on Aromatic Amino Acid and Downstream Phenylpropanoid Biosynthesis
Arogenate dehydratases (ADTs) perform the final step of phenylalanine (Phe) biosynthesis in plants. As one of twenty protein-coding amino acids, Phe is essential in all living organisms, and in plants it is also a precursor ...
Investigating the Electron Transfer Systems of the Endoplasmic Reticulum Membrane in Plants
Within the endoplasmic reticulum membrane there are two electron transfer systems (ETS): NADPH:cytochrome P450 reductase (ATR) transfers electrons to cytochrome P450 monooxygenases and NADH:cytochrome b5 reductase (CBR1) ...
SPECIFIC RESIDUES WITHIN HISTONE H2B REGULATE YEAST GENE EXPRESSION AND SILENCING, HISTONE H3 METHYLATION AND THE RESPONSE TO DNA DAMAGE
The histone proteins H3 and H4 have been extensively studied and are known to play well characterized roles in the regulation of yeast gene expression, silencing and the response to DNA damage. In contrast, relatively ...